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data trial_id
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We will now compare two CS treatment regimens: short course (72 hours only) of high dose versus more conventional, moderate dose therapy over 14 days in terms of efficacy and adverse events (AE). At the same time, we will continue our work to delineate the aetiological factors and inflammatory processes underlying AECOPD.This project will test the following hypotheses:1 Systemic CS are effective during AECOPD because of a rapid reduction in neutrophil chemotactic cytokines and down-regulation of neutrophil-related vascular adhesion molecules; this occurs over the first 2-3 days of therapy.2. Thus, short-course, high-dose CS therapy is as efficacious in the treatment of AECOPD as a more conventional 14-day course of moderate dose CS, but with significantly less risk of AE and without rebound of inflammation after cessation. Hospital length of stay can be reduced.3.Exacerbations over the subsequent one month (treatment failure) are no more frequent with short versus conventional course CS therapy.4. Viral and bacterial organisms isolated from sputum during an AECOPD are associated with a greater inflammatory response within the airway than non-infective exacerbations, but both are responsive to CS therapy.Specific aims are:1.To build on our preliminary findings of a rapid reduction in sputum neutrophilia and improvement in symptoms by systemic CS during AECOPD and to examine whether this relates to inhibition of neutrophil-related chemotactic factors and vascular adhesion molecules. 2.To compare short-course (3 day), high dose CS treatment and more conventional 14-day moderate dose CS therapy with focus on clinical outcomes, reductions in airway inflammation, rebound exacerbation and adverse events. 3.To identify bacterial and viral organisms as well as determine bacterial load at admission and to then relate these to airway inflammation, response to treatment and rate of rebound.', ''), ('Trial_Details_Control_Update_Value_Step3_10', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_10', 'Reason:', '', 'hidden'), ('', 'Trial website:', '', ''), ('Trial_Details_Control_Update_Value_Step3_11', 'Update:', u'', 'hidden'), ('', 'Presentations / publication list:', '', ''), ('Trial_Details_Control_Update_Value_Step3_12', 'Update:', u'', 'hidden'), ('', 'Name:', 'Dr David Reid', ''), ('Trial_Details_Control_Update_Value_Step3_13', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_13', 'Reason:', '', 'hidden'), ('', 'Address:', 'Clinical School of Medicine\n43 Collins Street\nHobart TAS 7001', ''), ('Trial_Details_Control_Update_Value_Step3_14', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_14', 'Reason:', '', 'hidden'), ('', 'Country:', 'Australia', ''), ('Trial_Details_Control_Update_Value_Step3_15', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_15', 'Reason:', '', 'hidden'), ('', 'Tel:', '+61 3 62267043', ''), ('Trial_Details_Control_Update_Value_Step3_16', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_16', 'Reason:', '', 'hidden'), ('', 'Fax:', '+61 3 62264894', ''), ('Trial_Details_Control_Update_Value_Step3_17', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_17', 'Reason:', '', 'hidden'), ('', 'Email:', 'D.E.C.Reid@utas.edu.au', ''), ('Trial_Details_Control_Update_Value_Step3_18', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_18', 'Reason:', '', 'hidden'), ('', 'Name:', 'Dr Himanshu Garg', ''), ('Trial_Details_Control_Update_Value_Step3_19', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_19', 'Reason:', '', 'hidden'), ('', 'Address:', 'Clinical School of Medicine\n43 Collins Street\nHobart TAS 7001', ''), ('Trial_Details_Control_Update_Value_Step3_20', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_20', 'Reason:', '', 'hidden'), ('', 'Country:', 'Australia', ''), ('Trial_Details_Control_Update_Value_Step3_21', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_21', 'Reason:', '', 'hidden'), ('', 'Tel:', '+61 3 62264846', ''), ('Trial_Details_Control_Update_Value_Step3_22', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_22', 'Reason:', '', 'hidden'), ('', 'Fax:', '+61 3 62264894', ''), ('Trial_Details_Control_Update_Value_Step3_23', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_23', 'Reason:', '', 'hidden'), ('', 'Email:', 'hgarg@utas.edu.au', ''), ('Trial_Details_Control_Update_Value_Step3_24', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_24', 'Reason:', '', 'hidden'), ('', 'Name:', '', ''), ('Trial_Details_Control_Update_Value_Step3_25', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_25', 'Reason:', '', 'hidden'), ('', 'Address:', '', ''), ('Trial_Details_Control_Update_Value_Step3_26', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_26', 'Reason:', '', 'hidden'), ('', 'Country:', '', ''), ('Trial_Details_Control_Update_Value_Step3_27', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_27', 'Reason:', '', 'hidden'), ('', 'Tel:', '', ''), ('Trial_Details_Control_Update_Value_Step3_28', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_28', 'Reason:', '', 'hidden'), ('', 'Fax:', '', ''), ('Trial_Details_Control_Update_Value_Step3_29', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_29', 'Reason:', '', 'hidden'), ('', 'Email:', '', ''), ('Trial_Details_Control_Update_Value_Step3_30', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_30', 'Reason:', '', 'hidden'), ('', u'', u'', '')] 14
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[] 19
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Respir Med. 2008;102(5):738-43.3.\tWalters J, Johns DP, Blizzard L, Walters EH, Wood-Baker R. Effects of 4.\tfeedback on spirometry in primary care on motivation for smoking cessation. Journal of Smoking Cessation. 2009;4(1):34-41.5.\tWalters J, Wood-Baker R, Walls J, Johns D. Stability of the EasyOne ultrasonic spirometer for use in general practice. Respirology. 2006;11(3):306-10.6.\tWalters JA, Hansen E, Mudge P, Johns DP, Walters EH, Wood-Baker R. Barriers to the use of spirometry in general practice. 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u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_8', 'Reason:', '', 'hidden'), ('', 'Secondary sponsor:', u'None', ''), ('', 'Name:', u'Nil', ''), ('', 'Address:', u'', ''), ('', 'Country:', u'', ''), ('', 'Other collaborator:', u'', ''), ('', 'Has the study received approval from at least one ethics committee?', 'Yes', ''), ('Trial_Details_Control_Update_Value_Step3_9', 'Update:', u'', 'hidden'), ('Trial_Details_Control_Update_Reason_Step3_9', 'Reason:', '', 'hidden'), ('', 'Ethics Committee name:', u'RCH Melbourne', ''), ('', 'Address:', u'', ''), ('', 'Country:', u'Australia', ''), ('', 'Date of approval:', u'', ''), ('', 'HREC Number:', u'', ''), ('', 'Countries of recruitment:', u'Australia', ''), ('', 'Brief summary:', 'The need for supplying fluids in paediatric bronchiolitis (severe viral airway infection of the infant) is frequent, and is the consequence of reduced feeding, sweating, and fever., There are currently 2 means of supplying fluids, intravenous or nasogastric.Nasogastric rehydration (NR) means giving fluids through a feeding tube inserted through the nostrils into the stomach thus eliminating the effort of drinking. It is generally effective and has few complications. Intra venous rehydration (IR) means giving fluids directly into a vein through a drip. It is often difficult to insert a drip in this particular age group, whereas the nasal feeding tube is generally easier to insert. The potential complications of IR are water overload and electrolyte imbalances. The main possible complications of NR is vomiting. The role of NR in bronchiolitis is, however, controversial. It is, for example, an accepted treatment in Scandinavia and Switzerland, whereas IR is the accepted treatment at the RCH Melbourne. Even within Australia there is no standard of care as such among the different hospitals with most hospitals using a combination of NR and IR, without any guidelines. The little existing evidence shows that NR in bronchiolitis is safe and well tolerated.The major concern raised with NR is the partial obstruction of the airway, by cousing ablockage of the nostril in young children who mostly breathe through the nose, thus theoretically causing further breathing problems. 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